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Los Angeles Pauses Johnson & Johnson Vaccine After Federal Recommendation Over Blood Clot Concerns

Concerns about the Johnson & Johnson COVID-19 vaccine were raised this morning following reports that federal health agencies have recommended an immediate pause in use of the single-dose shot after six U.S. recipients developed serious blood clots.

While Los Angeles and Orange counties, and the state, did not immediately say what that could mean for area vaccination sites, the City of L.A. is going to pause use of the Johnson and Johnson vaccine, KNX radio reported Tuesday morning. The Los Angeles Times later confirmed the report wit local health officials.

One vaccination site — a mobile site in Wilmington — will switch to the two-dose Pfizer vaccine, City Councilman Joe Buscaino said.

Buscaino issued a statement Tuesday saying, “City of Los Angeles Mobile Vaccine Site which begins vaccinations today (Tuesday) in Wilmington will switch from its intended Johnson & Johnson vaccine distribution to Pfizer today.”

CBSLA, meanwhile, quoted an L.A. Fire Department spokesperson as saying the vaccination site at Cal State Los Angeles would be offering people with Johnson & Johnson appointments the option of getting a Moderna or Pfizer vaccine, based on eligibility.

L.A. County this week received an allocation of 323,470 doses of vaccine — including Johnson & Johnson, Pfizer and Moderna. That represents an overall drop of roughly 80,000 from last week, due to a major reduction in supply of the Johnson & Johnson vaccine.

County health officials were anticipating supplies of the Johnson & Johnson vaccine to being increasing again in the coming weeks — but now new questions could change plans.

According to joint statement from the Food and Drug Administration and the U.S. Centers for Disease Control, the federal government is recommending an immediate pause in the use of the Johnson & Johnson vaccine nationwide after the six U.S. recipients — all women between the ages of 18 and 48 — developed serious blood clots within two weeks of getting vaccinated.

One woman died and a second woman in Nebraska was hospitalized in critical condition.

“We are recommending a pause in the use of this vaccine out of an abundance of caution,” Dr. Peter Marks, director of the FDA’s Center for Biologics Evaluation and Research, and Dr. Anne Schuchat, principal deputy director of the CDC, said.

“This is important, in part, to ensure that the health care provider community is aware of the potential for these adverse events and can plan for proper recognition and management due to the unique treatment required with this type of blood clot.

The statement also emphasized that the adverse reactions to the J&J vaccine “appear to be extremely rare.”

“More than 6.8 million doses of the Johnson & Johnson (Janssen) vaccine have been administered in the U.S,” the statement said. “CDC and FDA are reviewing data involving six reported U.S. cases of a rare and severe type of blood clot in individuals after receiving the J&J vaccine.

“In these cases, a type of blood clot called cerebral venous sinus thrombosis (CVST) was seen in combination with low levels of blood platelets (thrombocytopenia). All six cases occurred among women between the ages of 18 and 48, and symptoms occurred 6 to 13 days after vaccination.

“Treatment of this specific type of blood clot is different from the treatment that might typically be administered. Usually, an anticoagulant drug called heparin is used to treat blood clots. In this setting, administration of heparin may be dangerous, and alternative treatments need to be given.”

The CDC will convene a meeting of its Advisory Committee on Immunization Practices on Wednesday to further review these cases and assess their potential significance.

Dr. Anthony Fauci addressed the news today during the White House Covid-19 Response Team’s television update. “One of the questions that comes up already rather frequently is, ‘Does this have anything to do with the efficacy of the vaccine?’ So we know that there have been 6.85 million doses of J&J distributed in the United States thus far. Someone who had it maybe a month or two ago might say, ‘What does this mean for me?’ It really doesn’t mean anything. You’re OK because if you look at the time frame when this occurs, it’s pretty tight — from a few days, six to 13 days, from the time of the vaccination.”

Published reports quoted a Johnson & Johnson statement as saying, “At present, no clear causal relationship has been established between these rare events” and the company’s vaccine.

“We continue to work closely with experts and regulators to assess the data and support the open communication of this information to healthcare professionals and the public,” the statement added.

City News Service contributed to this report.

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